PD 166866
PD-166866 (PD166866)
CAS: 192705-79-6
Molecular Formula: C20H24N6O3
PD 166866 - Names and Identifiers
| Name | PD-166866 (PD166866) |
| Synonyms | CS-2496 PD 166866 PD-166866 PD-166866 (PD166866) FGF Receptor Tyrosine Kinase Inhibitor tert-butyl (2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)carbamate 1-(2-aMino-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl)-3-(tert-butyl)urea N-[2-AMino-6-(3,5-diMethoxyphenyl)pyrido[2,3-d]pyriMidin-7-yl]-N'-(1,1-diMethylethyl) |
| CAS | 192705-79-6 |
PD 166866 - Physico-chemical Properties
| Molecular Formula | C20H24N6O3 |
| Molar Mass | 396.44 |
| Melting Point | 291-293°C |
| Solubility | DMSO: ≥10mg/mL |
| Appearance | Off-white solid |
| Color | off-white to light tan |
| Storage Condition | 2-8°C |
| In vitro study | PS166866 can cause mitochondrial defects and oxidative stress. PD 166866 inhibits human full-length FGFR-1 tyrosine kinase with IC50 of 52.4±0.1 nM, but at concentrations as high as 50 μm, it inhibits c-Src, PDGFR-β, EGFR or insulin receptor tyrosine kinase, MPK, PKC and CDK4 had no effect. PD166866 is a potent inhibitor of bFGF-mediated receptor autophosphorylation in NIH 3T3 cells expressing endogenous FGFR-1 and L6 cells overexpressing human FGFR-1 tyrosine kinase. In vascular smooth muscle cells, A432 or NIHIR cells, PD166866 had no inhibitory effect on PDGF, EGF or insulin-stimulated receptor autophosphorylation, indicating a high selectivity of FGFR-1. In addition, PD166866 inhibits microvascular growth (angiogenesis) in cultured human placental artery fragments. In L6 cells, 42-and 44-kDa MAPK were inhibited with an IC50 of 7.9 nM and 4.3 nM, respectively. PD166866 can inhibit autophagy by inhibiting Akt/mTOR signaling pathway. |
PD 166866 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 1 |
PD 166866 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.522 ml | 12.612 ml | 25.224 ml |
| 5 mM | 0.504 ml | 2.522 ml | 5.045 ml |
| 10 mM | 0.252 ml | 1.261 ml | 2.522 ml |
| 5 mM | 0.05 ml | 0.252 ml | 0.504 ml |
Last Update：2024-01-02 23:10:35
PD 166866 - Reference Information
| biological activity | PD-166866 is a synthetic small molecule that inhibits the tyrosine kinase activity of FGFR1, it is highly selective for FGFR1 and inhibits the self-phosphorylation activity of FGFR1. |
| Target | TargetValue FGFR1 (Cell-free assay) 52.4 nM |
| Target | Value |
| FGFR1 (Cell-free assay) | 52.4 nM |
| In vitro studies | PS166866 can cause mitochondrial defects and oxidative stress. PD 166866 inhibits human full-length FGFR-1 tyrosine kinase with IC50 of 52.4±0.1 nM, but at concentrations as high as 50 μm, it inhibits c-Src, PDGFR-β, EGFR or insulin receptor tyrosine kinase, MPK, PKC and CDK4 had no effect. PD166866 is a potent inhibitor of bFGF-mediated receptor autophosphorylation in NIH 3T3 cells expressing endogenous FGFR-1 and L6 cells overexpressing human FGFR-1 tyrosine kinase. In vascular smooth muscle cells, A432 or NIHIR cells, PD166866 had no inhibitory effect on PDGF, EGF or insulin-stimulated receptor autophosphorylation, indicating a high selectivity of FGFR-1. In addition, PD166866 inhibits microvascular growth (angiogenesis) in cultured human placental artery fragments. In L6 cells, 42-and 44-kDa MAPK were inhibited with an IC50 of 7.9 nM and 4.3 nM, respectively. PD166866 can inhibit autophagy by inhibiting Akt/mTOR signaling pathway. |
Last Update：2024-04-09 21:54:55
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Product Name: PD-166866 (PD166866) Visit Supplier Webpage Request for quotationCAS: 192705-79-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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